Threats of Concomitant Use or Discontinuation of Cytochrome P450 2D6 Inhibitors The concomitant use of tramadol hydrochloride tablets with all cytochrome P450 2D6 inhibitors (e.g., amiodarone, quinidine) may perhaps cause an increase in tramadol plasma stages plus a lower from the amounts of the Energetic metabolite, M1.Frequently reevaluate people